Intra-articular administration of B-cell line transfected with Flt3-L gene resulted in highly erosive arthritis while inoculation of the same B-cell line without hyperexpression of Flt3-L did not induce erosivity and only in a minority of cases caused synovial proliferation!
Such extrinsic reporters of protein conformation can — albeit in a minority of cases — cause artefacts or perturb the protein or interaction being studied [2].
Acute bronchitis often occurs in conjunction with viral infections such as common cold (e.g., rhinovirus, adenovirus), respiratory syncytial virus, or influenza, with a minority of cases caused by bacterial infections.
Most are caused by viruses such as rhinovirus, coronavirus, adenovirus, or respiratory syncytial virus, although a minority of cases is caused by bacteria [ 12].
Just like alcohol, excessive use can - in a minority of cases - cause problems for other passengers and airline crew".
A small minority of cases are caused by autosomal dominantly inherited mutations in the presenilin 1 (presenilinesenilin 2 (PSEN2) or amyloid precursor protein (APP) genes, or by APP duplications.
The large majority of AD cases are of sporadic nature, showing inefficient removal of Aβ [ 2], whereas a minority of cases is caused by genetic mutations (familial AD) with an onset typically below age 65 years.
The clinical consequences and aetiology of these multiple epimutations are mostly unclear, though in a minority of cases a rare genetic cause may be identified and in others there is an association with a history of conception by assisted reproductive technology (ART) [ 9- 11].
A minority of mutations causes the production of structurally abnormal type V collagen, the secretion of which may be impaired but not completely abolished [5], [6], [7].
