According to three independent empirical studies [ 39– 41], this significant increase in TBP affinity for the minor variant of the IL1B promoter corresponds to overexpression of this gene (designated as ↑ in Tables 1– 3).
It has enough simplicity that minor variants of standard numerical Hamiltonians developed for uniform grids can be applied, yielding consistent, monotone, convergent schemes.
So for genuinely innovative technologies that cannot plausibly be lumped as minor variants of existing and proven technologies, there is little choice but to bear the brunt of the full force of the U.S. regulatory hammer.
I was glad to see such an article in The Times, for year after year pieces featuring men's fashions merely display minor variants of the same boring, boring, boring garments.
Evolutionary processes can only select from among minor variants of what is there already.
The molecular basis for this phenomenon would lie on the rapid adaptation of certain viruses to a changing environment through selection of minor variants from quasispecies, accumulation of mutations, recombination between minor variants, and reassortment of their genomes.
There were no minor variants of subtypes 4 and 5.
Two of the four cell strains selected for analysis are heterozygote for the minor variant haplotype of p53, a cell cycle control gene (cell strains 3 and 4).
Combining the 454 and Sanger datasets resulted in 296 additional NAGNAG AS events being detected - of these, 66 had strong support for AS in terms of satisfying the criteria used to define the training dataset (≥ 2 reads for each variant, ≥ 10% of the reads for the minor variant).
The SeqScape v.2.5 (AB) was set up to automatically detect the presence of heteroplasmic-like patterns involving at least 15% of the signal for the minor variant; in addition, all the electropherograms were inspected visually.
