Here we show that the response mounted against the accessible virion surface is dominated not by gH/gL-a comparatively minor target-but by the non-essential gp150.
Expression profiling indicated that 158 H2O2-induced genes were dependent on the function of Atf1 and/or Pcr1, of which, 45 were the major Atf1/Pcr1 binding targets and 50 were the minor targets.
Taken together, these studies point to Ser as the potentially major CHEK2 substrate in BRCA2, with additional minor targets including Serine, Serine, and Threonine.
We speculate that the ALG-2-bound mirtrons and other DGCR8-independent miRNAs that repress genes required for adaptation are more active as they have no competition for ALG-2 and thus much of the ALG-2 function is redirected to minor targets; targets might include genes that are required for adaptation, such as OSM-9 and EGL-4.
Our analysis of Canadian consent template texts on secondary use, sharing of data and material, and recontacting participants, in the context of genetic research, shows that only minor, targeted modifications would be required to increase the protection of participants in NGS research.
Minors targeted in this and other offender studies (e.g. Seto et al. 2011) would suggest that they are likely to be adolescents.
Two different alignment strategies, based on a putative kinetoplast DNA minor groove target, were used.
Among these, certain small-molecule translation inhibitors have attracted a great deal of attention, due to their relatively high selectivity against prokaryotes, and an appropriate therapeutic index with minor "off target" effects.
Although gH/gL-specific monoclonal antibodies can block infection at a post-binding step close to membrane fusion, gH/gL is a relatively minor antibody target in virus carriers.
