I had a full hysterectomy and minor resections of my bladder, rectum and vagina.
We considered patients 70 years of age, post-operative complications, diagnosis, extension of resection (major resection, minor resection, resection of nodules), overall and disease free survival at 48 months.
The 19% underwent to major resection, 60% to minor resection and 21% resection of nodules.
In our study, compared to patients with a minor resection, the OS of the patients who underwent major resections was significantly better (P = 0.036).
If no major resection could be identified for an individual, then their hospital episodes were searched again for other surgical interventions in the order of minor resection and then palliative procedures such as bypass, formation of a stoma or insertion of a stent (defined using the OPCS4 (NHS Connecting for Health, 2009a, 2009b) codes in Appendix 1).
A major resection was defined as removal of at least three liver segments, and a minor resection was defined as removal of two or fewer than two segments.
It seems unlikely that this is entirely a consequence of the minor resection defect in siINO80 cells, and it therefore suggests that INO80 has an additional function in promoting RAD51 foci formation during HR.
Therefore, we excluded episodes of hospital activity 28 days to 6 months before diagnosis if there was no record of colonoscopy, major or minor resection, or inpatient or outpatient treatment in general surgery, colorectal surgery or gastroenterology.
The comparison of outcomes between major and minor resection suggest a wider surgical margin for tumor resection may lead to better survival for the patients, which is supported by studies on liver metastases from colorectal cancer [ 26].
A hierarchy of primary procedures occurring within 12 months of diagnosis was established: major resection; minor resection; palliative procedures.
