Sentence examples for minor predisposition from inspiring English sources

However, we noticed that the occurrence of prostate cancer in these mice can be seen only in aged mice with a low frequency, implying that Men1 inactivation may confer a relatively minor predisposition to prostate cancer development compared with the endocrine tissues affected in MEN1 pathology and that other factors may be involved in the development of this pathology.

Despite being expressed ubiquitously in adult tissues, germline mutations in BRCA1 predispose individuals to breast and ovarian tumors with only minor effects on the predisposition to cancer in other sites.

Therefore, the EPHB family likely accounts for a minor proportion of genetic predisposition to colorectal cancer but has an important role in tumor progression.

They proposed that the smaller cross-sectional diameter combined with increased body mass and minor trauma created a predisposition to fracture in these patients.

While this does not exclude the possibility that NER gene polymorphisms might make a minor contribution to genetic predisposition to colorectal cancer, a much larger study than the present one would be required to identify such a minor risk factor.

Common migraine is a polygenic disease i.e. several genes have minor contributions to its pathophysiology and genetic predisposition combines with environmental triggers to cause clinical symptoms.

We have carried out association studies to search for common variants (minor allele frequency >5 10%) that contribute to predisposition,.

Haplotype CAG, which exactly corresponds to the major allele of rs266729, was associated with protection from CAD (P < 0.001), whereas haplotype GAG, exactly corresponding to the minor allele of rs266729, was associated with predisposition (P < 0.001).

Reduction to homozygosity of cancer predisposition SNPs may also play a minor role.

We have also performed an extensive literature review to investigate the role of the reported nsSNPs (minor allele frequencies ≥5%) in human cancer predisposition (Table III).

The rs1799950 SNP is one of 25 SNPs in cancer predisposition genes that were identified to confer minor but cumulatively significant risk of breast cancer [ 21].