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Of course, it might be equally possible that the originally reported minor pattern completion deficit in CA3-NR1 knockout mice may have resulted from behavioral variations during those particular sets of experiments (it is noted that an unusually large group of control mice were used in comparison with a much smaller group of mutant mice).
Some strains showed minor pattern profiles already present among C 2b P1.2,5 isolates (PT1, PT4, and PT38, all of them closely related to PT7 and PT8).
Experts' described (avoiding) harm in a variety of ways (table 2), with two main patterns and a third minor pattern emerging.
Midway through the transformation, at the stage when cells switch from slow to fast growth rate, the major transcription pattern undergoes a total inversion of its weight while the more minor pattern does not contribute before that stage.
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Successive clustering with increasing cluster number reflected this finding showing first the main expression patterns and subsequently the minor patterns.
The major pattern is important throughout while more minor patterns typically contribute significantly only early or only later on.
A challenge in analyzing single cell data sets involves finding both the major and minor patterns that characterize cell populations.
The stronger bands of the minor patterns fall half-way between the bands of the main pattern, and the smallest is 120 to 130 nucleotide pairs long [ 58].
Any minor patterning abnormalities would likely be manifest in the skeleton, since secreted BMP2 plays an important role in skeletal development and limb patterning.
Results from this study extend the previous analysis to a broader chemical landscape, revealing both major and minor patterns for groups of chemicals and biochemical assays.
Revealing these rare cells in conjunction with larger subpopulations demonstrates the usefulness of our PCA-based statistical workflow to highlight major and minor patterns.
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