Sentence examples for minor mutations in from inspiring English sources

In the former, natural variation entails the gradual accumulation of minor mutations in alleles.

Similarly, minor mutations in human XPG that impair its NER function lead to XP symptoms, but truncating mutations additionally cause severe CS-like symptoms.

Further transition from a dsRNA to a dsDNA world could be based on minor mutations in template and substrate recognition sites of an RNA polymerase and would leave all existing processes intact.

While the previous analysis of the amino acid sequences of these proteins identified critical differences at some conserved sites in the primase domain region of the protein in metazoa, including the absence of the cysteine residues needed to form the zinc fingers [ 4, 5], we wanted to know if these changes were due to minor mutations in the sequence.

These random parameter perturbations can be thought of as minor mutations in the network components which do not form part of the parsimonious set of evolutionary changes along the lineage to S. cerevisiae, but which may nevertheless have occurred and subsequently been lost.

In the book as well, the authors suggest our language capacity was "the result of a minor mutation" in genomic terms that had far-reaching changes in our capacities.

Because polyclonal antibodies were employed, the established test strip might have an ability to detect CT in various isolates even if some minor mutation in antigen was occurred in it.

The relatively limited number of sequenced quasispecies does not allow us to exclude potential artifacts of sequencing, and it is possible that at least some transient or minor mutations observed in this study are not true mutations.

The second selection process would allow minor mutations to occur in the DNA coding sequence, leading to amino acid selection and functional maintenance of the proteins under fluctuating environmental conditions.

34 A summary of the raltegravir resistance profile due to various key and minor mutations is shown in Figure 3. Subgroup analysis of the data from BENCHMRK studies found that at 48 weeks of treatment with raltegravir in combination with OBT, 23% of the drug recipients suffered virologic failure.

Genetic studies by Oxford team member Sophie Kahn, not yet published, indicate that only minor mutations underlie the variations in these three morphs, says Rainey.