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There were no significant treatment-related increases in minor malformations or variations (Table A7).
Minor malformations (i.e. skin tag) were reported as normal unless they were associated with another abnormality.
The 12 cases classified as only minor malformations according to the EUROCAT classification were excluded.
Cases with only minor malformations account for approximately 10% of all BDs registered.
We did not include minor malformations in our analyses unless they were disfiguring or required treatment.
However, six of these (86%) had additional major and/or minor malformations.
Similar(39)
Approximately 14% of neonates are born with a single minor malformation and around 2 3% are born with major malformations.
But the study found that children conceived via ICSI had a somewhat higher rate of minor genital malformations.
Three subjects were excluded from further analysis due to minor vascular malformations and a temporal lobe cyst.
There was nothing unusual, statistically or otherwise, about the 3 major and 2 minor congenital malformations observed among the offspring.
A recent systematic review found that 23% of pregnancies exposed to MTX in the first trimester resulted in spontaneous abortion and 5% of pregnancies resulted in reported minor neonatal malformations.
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