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Although sharing 68% amino acid sequence identity to ABR [25], [26], BCR overexpression had only a minor inhibitory effect on insulin-induced AKT phosphorylation (data not shown).
The fact that 1 mM TEA had only a minor inhibitory effect on these currents also argues against a major role of Kv1.1 and Kv3.1 for which IC 50 values of TEA are 3 to 10 times lower than this concentration (table 1; [28], [28]).
To determine whether there was minor inhibitory effect of the RNA from the contents of the pig intestine on qPCR amplification, the levels of amplification for espD and tir were quantified by addition of cDNA from broth grown bacteria to the cDNA from the contents of control loops at ratios 1∶1 to 1∶5.
The investigation of enzyme activity of GSK3β showed a minor inhibitory effect compared to the analogue substance SB-216763.
Thus, the Ad vectors applied in this study seem to have no or a minor inhibitory effect on the RNAi response in vitro and in vivo.
Pre-treatment with CsA or TAC had no effect or a minor inhibitory effect on IL-1RA release by neutrophils following pro-inflammatory stimulation.
Similar(47)
Aqueous fractions generally displayed minor inhibitory effects, with the exception of fractions from P. acerosa and P. homomalla, which inhibited GST activity by 85 % and 99, respectively.
GB39 and GB40 had minor inhibitory effects on JAK1/Tyk2 (Table 2), which indicated that GB39 and GB40 have the potential to be JAK/STAT3 signaling pathway-specific inhibitors.
Pre-treatment of neutrophils with CsA, TAC, SIR or EVE had no effect (CsA, TAC, EVE) or minor inhibitory effects (SIR, −21%) on the basal adhesion of neutrophils to HUVECs.
Exposure of cells with low intralumenal content of CyPB to CsA had a minor, additional inhibitory effect on BACE457Δ disposal (lane 6 vs lane 5) possibly due to the inhibition of the residual CyPB remaining in the cells subjected to specific RNAi (Fig. 2A, lane 2).
Notably, however, while Fc-CD95L and TRAIL potently induced apoptosis in both cell lines within 18 h, treatment with soluble TNF, thus TNFR1 activation, elicited no or only a very minor growth inhibitory effect.
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