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The sensitivity to predict minor histopathologic response was 20.8%, with a specificity of 100% (P=0.15).
This association is statistically not significant (P=1), with a low sensitivity (54.1%) and specificity (65%) to predict minor histopathologic response.
Regression grades III and IV were considered as major histomorphologic response (MaHR) compared to grades I and II constituting minor histopathologic response (MiHR).
The sensitivity for detection of a minor histopathologic response was 41.6% for the whole group, 42.8% for squamous cell cancers and 40% for adenocarcinomas with a specificity of 100% in all the three groups.
A significant association between quantitative c-erbB-2 but not c-erbB-1 mRNA expression levels in oesophageal cancers and minor histopathologic response to CDDP/5-FU-based neoadjuvant radiochemotherapy could be demonstrated.
We therefore applied histopathologic criteria instead of inaccurate clinical restaging modalities for objective response evaluation in neoadjuvant-treated oesophageal cancers and identified a significant association between minor histopathologic response and dichotomised relative c-erbB-2 mRNA expression levels (P<0.01).
Similar(49)
The purpose of this prospective study was to investigate the potential of quantitative c-erbB-1 and c-erbB-2 mRNA expression in pretreatment biopsies to predict a minor or major histopathologic response to neoadjuvant therapy with CDDP, 5-fluorouracil (5-FU) and simultaneous radiation (36 Gy), followed by surgical resection in oesophageal cancers.
The pooled sensitivity and specificity of FDG-PET/CT in predicting histopathologic response in primary breast cancer is 81 and 79%%, respectively [40].
We identified no association between change in CA 19-9 and histopathologic response (P = 0.74 .Although the PPV of CA 19-9 for completing neoadjuvant therapy and undergoing PD was high, its clinical utility was compromised by a low NPV.
The overall histopathologic response rate was 17.9%.
pCR and MRD were defined as histopathologic response and GRD as no histopathologic response.
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