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On the other hand, the eosinophilia described by Sayegh et al. was not confirmed in our two patients, who showed a normal total WBC count, with minor elevation of neutrophil percentage but normal neutrophil count.
Importantly, zaprinast treatment resulted only in a minor elevation of cell death in PARP1 KO retina when compared to zaprinast treated wt (PARP1 KO + zaprinast: 0.7% ±0.04 SEM, n = 5, p<0.01) (Fig. 3N, O).
The homozygous deletion (DD) genotype is associated with minor elevation of serum ACE activity: individuals with this genotype have 60 70% more ACE in the blood than carriers of the II genotype and approximately 30 40% more than the whole population mean [33], [71].
No significant changes occurred in the monitored serological parameters, except for minor elevation of antinuclear antibodies.
Those animals which survived exhibited similar signs and symptoms including minor elevation of pulmonary pressure and right heart hypertrophy which was not significant compared to the control animals.
Inflammation is a key component of atherosclerosis [ 55], and it is well established that even a relatively minor elevation of inflammatory markers (such as C-reactive protein) is predictive of cardiovascular events in the general population [ 56].
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However, the overall risk of cancer is still small, especially with minor elevations of calcium levels.
One interesting notion in this regard is the large differences seen in mycoplasma pneumonia with highly elevated expression of CD64 on neutrophils compared to healthy persons in contrast to minor elevations of B-HNL and PCT levels.
Our third patient had a minor elevation in blood pressure only.
Figure 1B shows that 1 mg/ml of TiO2 NPs induced an approximate 150% increase, while lower TiO2 concentrations (<0.1 mg/ml) caused a minor elevation (∼110%) in [Ca2+]C when compared with untreated cells.
There is a minor elevation in manganese in the one evolved isolate from population IR-4-20 (CB4000) and in some strains derived from the further evolution of CB1000.
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Justyna Jupowicz-Kozak
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