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Although lineage-specific genes identified on minor chromosomes could result from assembly issues, we identify hundreds on major chromosomal arms (Table 5), suggesting that many of these are in fact cases of lineage-specific gene formation.
A study with H. mediterranei minichromosome pHM300 suggests that the replication of the major and minor chromosomes is controlled independently [ 74], and we suspect that this may be the case also in H. volcanii.
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Two distinct chromosomal loci, termed major (chromosome 3) and minor (chromosome 12), harbor the globin genes containing α/β pairs in a 5′ 3′ to 3′ 5′ orientation.
Strain LB400 has one of the largest bacterial genomes (9.73 Mbp), distributed in a major chromosome (C1), a minor chromosome (C2) and a megaplasmid (MP).
Moreover, subsequent minor chromosome changes and/or differences in condensation due to epigenetic modifications of chromatin may further blur chromosome morphology.
Plasmid pSKT10 harbored transposon-tagged DNA from the minor chromosome pHV3, whereas pSKT11 and pSKT12 contained tagged DNA from the main chromosome (Table 1).
Because the two QTL have minor chromosome-significant levels, they are very likely to be false positives and need further study.
The QTL at 4 cM/1.25 on GGA2 and 48 cM/3.81 on GGA28 have minor chromosome-significant levels and without some confirming data, which are very likely to be false positives.
Although 40 million years of evolution separate chickens and turkeys, only 30 minor chromosome rearrangements were detected between the two and their karyotypes are strikingly similar [ 3].
All cases show multiple whole chromosome gains and some cases also minor chromosomal regions of gain.
The 299 SNPs and their annotations, such as dbSNP IDs, minor alleles, chromosome positions and nearby genes (within 500Kb), are provided in Additional file 2.> We sought to explore how these 299 SNPs differed among ethnic groups and calculated their minor allele frequency in each ethnic group.
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