Sentence examples for minor causal from inspiring English sources

For minor causal variants, deep sequencing of the regions of interest is required; 40, 41 3) Identification of causal variants with direct or indirect functional relevance to disease risk has proved to be difficult.

This fitness defect has three possible causes: (1) the recreated clones are missing minor causal alleles, which we failed to find; (2) detrimental mutations were introduced during the multiple transformations required to make the recreated strains; or, (3) the evolved clone (which is a mutator, unlike the recreated strain) continued to evolve and adapt during the competition.

Supplementary Figures 1 and 2 present power for a wider range of association models encompassing intermediate levels of allelic heterogeneity, where trait means are determined by the presence or absence of minor alleles at any causal variant, and by the proportion of causal variants at which a minor allele is present, respectively.

Determine the number of minor alleles across all causal variants carried by the ith individual, denoted m i.

We assumed that the expected trait value of each individual is increased by the presence of a minor allele at any causal variant.

However, even when the trait mean is determined by the presence or absence of a minor allele at any causal variant, RVT1 is generally more powerful than RVT2.

Gene 3 contained common variants, while genes 4, 5, 6, and 8 had a low sum of causal variants minor allele frequencies.

First, GWAS are designed to test the common variant common disease hypothesis, that is, they rely on LD between common markers and common causal variants (minor allele frequency (MAF) > 5%), and not low-frequency causal alleles.

Under the assumption that the trait mean is determined by the presence or absence of minor alleles at any causal variant, we simulate the phenotype, y i, of the ith individual from a N(I(m i > 0),σ) distribution.

They considered a model in which the expected trait value of an individual was increased by the presence of a minor allele at any causal variant in the gene.

This would suggest that RVT2 is less robust to the presence of minor alleles at non-causal rare variants than is RVT1.