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It was found that minor backbone structural variations, including linking group and the structural symmetry would affect the TE.
The rat enoyl-CoA hydratase contains a proline at position 170, which is absent in BvaB1 and BvaB2, which may cause minor backbone changes that prevent formation of the third hydrogen bond in the rat enoyl-CoA hydratase.
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Although less frequent, minor groove-backbone interaction has also been found in crystal structures of B-DNA duplexes (Table 1).
Thus, both major- and minor groove-backbone interactions appear to require GC base pairs for their sequence-dependent interactions in right-handed crossovers.
The incorporation of isosorbide succinate into PLLA main backbone had minor effect on the thermal stability and the Tg of the products.
DNA polymerase β primarily interacts with DNA through sequence independent interactions (sugar phosphate backbone and minor groove).
(3) DNA translocation is sensitive to changes in the DNA backbone as minor as a single missing phosphate group at a nick (Stanley et al, 2006).
A minor modification of the polymer backbone improved solvent resistance measurably.
All polymerase thumb domains interact with the backbone of the minor groove.
Only a minor change in the phosphate backbone conformation of the templating 8-oxoG is required to relieve the steric clash of O8 with the sugar phosphate backbone.
The plugin provides three distinct three-dimensional visualization modes to highlight interactions with DNA bases and backbone, major and minor groove, and with atoms of different pharmacophoric type (hydrogen bond donors/acceptors, hydrophobic and thymine methyl).
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