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It is well known that the minor alteration at the level of gene or protein expression usually leads to significant change in metabolite level.
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This article was amended by the author with minor alterations at 16:00 BST on 24 September 2010.
From the first patent the company filed in 1997 to the one it submitted in October, Mr. Appel says, it had to fix half a dozen major design flaws and make 400 minor alterations at the Carthage plant.
Certainly its authors noticed: they sued the rapper who, at first, claimed his minor alteration of the notes constituted a new composition.
It's a minor alteration of language that bespeaks a deep shift in perception.
He noticed a seemingly minor alteration in one section, the kind of thing most people would skip over.
Around this time, when he was travelling on business trips across Europe and the war was raging back at home, he decided to change his name from Buturovic to Butorovic, a minor alteration, but one which he figured would bring him greater respect when he stayed in grand western hotels.
In 50 mM K+ buffer, the double LNA-substitution at the diagonal positions of L2 (2, 11) showed a CD spectrum with a small difference from the natural TBA, suggesting a minor alteration of the native TBA structure (Figure 2B).
Despite the protests of local officials, his appellation stuck with the minor alteration to Lyme Disease.
Another minor alteration appears to address a related issue raised in the June HuffPost report.
The Wright design is thought to have been used without minor alteration until the late 1990s.
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