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They'll no longer be able to use the minimum value method, making stock option programs too expensive for most.
Therefore, in this work, the simpler minimum value method was used, as it worked well in practice.
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Also ruled out is the minimum-value method, which is what somebody would willingly pay for an option if they knew that the firm's share price would be fixed for the life of the option.
Note that the verification rate of pull-down assays obtained for the IVV method represents a minimum value because the method detects both direct and indirect interactions [19].
The criterion for selecting cut-offs was the minimum p-value method.
Because all four methods yielded similar results (Additional file 4) all downstream analyses focused on ProbeSets aggregated using the minimum p-value method.
For any variable not included by the FP method, the existence of a threshold effect (in which expression at or above a specified level predicts outcome) was checked by a minimum P-value method (Clark et al, 1993).
Afterwards, using the minimum p-value method on the log-rank test for OS in the discovery cohort, we determined the ideal cut-off for dichotomization of PPP2R2A (B55α) scoring (further details are provided in the Additional file 1) [ 22].
In univariate analysis high C35 expression (cut point AQUA score 304; minimum P-value method) was associated with worse overall survival, along with stage, ER status and chemotherapy regimen (Supplementary Table S1).
To dichotomize CXCR2 expression into high and low groups, the score of 200 was selected as the cutoff point according to the minimum p-value method based on its correlation with OS.
Monte Carlo simulation showed that the naïve search of the maximum C index will give rise to an estimation bias, which is very much like the positive bias that affects the minimum p-value method.
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