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Assuming a minimum treatment failure rate of 5% and a loss to follow-up of 10%, a sample size of 204 P. vivax patients would be needed for estimation with a 3% precision and at 5% significance level ("CSample" command/Epi Info 6).
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Because there was no evidence of treatment failure, the minimum sample size for ensuring 10% precision with a 95% confidence level (95% CI) was 96 patients.
The NABTs reported in the literature for patients with complete treatment failure (group 2) declined rather homogeneously (−0.0664; minimum: −1.1620; maximum: −0.0348; SD: 0.2897).
In a meta-analysis of seven randomized, controlled studies with a minimum treatment duration of 52 weeks in type-2 diabetic patients and no heart failure at baseline incident heart failure was rare (about1%) and there was a trend towards a reduced incidence of heart failure with acarbose (HR 0.55 (95%CI 0.21-1.45) [ 59].
We found that, even when the dose was administered as an extended infusion, up to 37% of the patients with ARC did not achieve this minimum PK/PD target - and may thus be at risk for treatment failure.
A minimum of 6 months of therapy may be necessary prior to declaring treatment failure.
It is possible that the minimum inhibitory concentration was not reached in some patients, with the associated risk of treatment failure [ 1, 2].
Treatment failure with inappropriate dosing is of particular concern for pathogens with a high minimum inhibitory concentration (MIC) [14, 49].
Treatment failure with inappropriate dosing is of particular concern for pathogens with a high minimum inhibitory concentration (MIC) [ 14, 49].
Treatment failure was a temperature of >/= 103.0°F during Treatment Period after a minimum of two hours post study drug or placebo.
Typhoid remains common in many developing countries, and increasing minimum inhibitory concentrations (MICs) to fluoroquinolones, such as ciprofloxacin and ofloxacin, correlate with increased fever clearance times and treatment failure (Parry et al., 2011).
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