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In addition, dual-frequency pretreatment could reduce minimum threshold dose of pretreatment time in this experiment.
We also demonstrated that 10 µg of TNF-α (a 5-fold reduction of the 'standard dose of 50 µg') was the minimum threshold dose for activity of TNF-α in our rat tumor extremity perfusion model.
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The lowest dose level in the trial was therefore likely to have been below the minimum effective threshold dose and above this level there was little evidence of a DI effect.
Further studies are needed in larger multi-institutional prospective trials: 1) to more firmly establish the minimum safe threshold dose for single unit UCB in adult patients treated with RIC, and 2) to identify key parameters for graft selection in the two UCB unit setting that may contribute to enhanced graft vs. malignancy effects confirmed in this prospective single institution study.
The target cell dose selected is lower than minimum threshold cell doses previously reported by other investigators in two-unit studies in adults treated with non-myeloablative conditioning.
Several proton implants were performed in order to find the threshold dose (minimum dose to achieve maximum sheet resistivity) for the electrical isolation of n-type GaNxAs1−x layers.
Radiation dose of 6-12 Gy has been reported as the minimum threshold level for development of RIFHD, and radiation dose positively correlates with frequency of RIFHD [50].
For each task and reconstruction algorithm, a threshold dose was derived as the minimum dose required to achieve a threshold AUC of 0.9.
Statistical analysis was performed using a repeated measures ANOVA for the individual groups of rats, comparing baseline sensory thresholds to the minimum threshold from 1 to 4 hours following each dose of acetate within each rat.
A dose-response phenomenon described as the minimum threshold for infection characterizes each vector-virus combination.
Thus, the production of allergen specific IgG antibodies may have the effect of increasing the minimum dose required to provoke an allergic response (i.e., increasing the threshold dose).
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