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To obtain realistic search results, the 100 most similar compounds with a minimum similarity of 0.5 were retrieved for each query.
Figure 7 The number of the Murcko frameworks in MDDR that are similar to those in ACD based on different minimum similarity of ECFP_6 fingerprint.
Figure 8 The number of the Murcko frameworks in ACD that are similar to those in TCMCD based on different minimum similarity of ECFP_6 fingerprint.
About 40.8% (2605/6386) of the Level 1 scaffolds in MDDR has similar Level 1 scaffolds in ACD, and 53.8% (2468/4588) of the Level 1 scaffolds in ACD has similar Level 1 scaffolds in MDDR. Figure 6 The number of the Murcko frameworks in MDDR that are similar to those in TCMCD based on different minimum similarity of ECFP_6 fingerprint.
To obtain a high specificity for the results, only the reads similar to a single transcript were computed, with a minimum similarity of 80%% and a read length alignment higher than 90%%.
Furthermore, we once more normalize the similarity values by subtracting for each user the minimum similarity of her direct neighbors.
Similar(43)
The following criteria were used to filter the unique sequence reads: minimum length fraction of 0.9; minimum similarity fraction of 0.8; maximum number of two mismatches.
Read mapping was performed using the CLC Genomics Workbench, version 6.0.1 (CLC bio A/S, Aarhus, Denmark), with a minimum length fraction of 0.9 and minimum similarity fraction of 0.95.
The resultant clean and high quality reads were mapped by CLC Genomics Workbench (using the minimum similarity fraction of 0.98, the minimum length fraction of 0.8 and the maximum number of hits of 10) against the improved apple reference transcriptome [ 25], which is available at URL http://www.rosaceae.org/species/malus/malus_x_domestica/CU_RNA_seq_genes of GDR [ 26].
EST assembling was executed using the CAP3 program, with a minimum similarity threshold of 90% and a minimum overlap of 40 bases.
For each spruce consensus sequence, the blastx hits with a minimum similarity value of 0.75 and a minimum coverage of 0.5 were used in the GO assignment procedure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com