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For the purpose of performance evaluation, two new sets of rscans are generated with minimum pore radius 0.055 mm and nonstandard high and low Ψcnr given by S/D = 50,000/270 and S/D = 30,000/200.
The application of EFT to our results (Figure 4B) predicted that the minimum pore radius was larger for WT HCN4 channels (3.5±0.2 Å) than previously estimated for K+ channels (∼1.7 Å) [15], [16], [41], [42].
Similar(58)
Therefore, the minimal pore radius at the intercellular gate level in the models of the Kv7.1 activated and intermediate states corresponds to the open pore.
Three sets of rscans with different minimum pore radii 0.055, 0.085, and 0.1 mm (maximum radius constant at 0.13 mm) are generated.
As a final setup and optimization step, the effect of different minimum radii in the pore radius distribution on the performance is explored.
The maximum of average pore radius is 139.74 μm, while the minimum value is 103.7 μm.
The sample is characterized with maximum pore radius of 173.9 μm, and a minimum radius of 0.01 μm, and an average pore size of 41.6 μm.
mean pore radius (nm).
effective pore radius.
The final sphere radius corresponded to the pore radius.
(b) Corresponding pore radius distribution curves.
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