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ΔPLT was obtained as follows: (platelet count when platelets started to decrease - minimum platelet count subsequently observed / the number of days required to observe the minimum platelet count after platelets started to decrease).
The minimum platelet count was noted in the first days after disease onset, whereas it normalized at the time of maximum creatinine levels.
Prior to each chemotherapy cycle, the minimum platelet count and neutrophil count permitted to receive treatment were 100×10 l−1 and 1.0×10 l−1, respectively.
The median minimum platelet count was marginally lower among those who died (34 × 10/L), compared with that among those who recovered (47.5 × 10/L; p = 0.054).
Takala and co-workers have studied 19 NE patients and 13 patients with other viral infections and detected an inverse correlation of serum IL-6 concentrations in NE patients with mean arterial pressure and minimum platelet count [ 24].
Pertinent laboratory values were the following: creatinine 2 mg/dL (baseline 0.8 mg/dL), aspartate aminotransferase 105 U/L, alkaline phosphatase 765 U/L, and minimum platelet count 40,000/mm.
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A minimum target platelet count of 75 × 10.l−1 is appropriate in this clinical situation.
Minimum level platelet counts were lower in knowlesi than in falciparum malaria (median 76,500/µL vs. 156,000/μL; p = 0.01).
As a minimum, PT/aPTT, platelet counts and the PFA-100® (Dade Behring, Frankfurt, Germany) test should be carried out in all Gaucher patients prior to elective surgery to assess bleeding risk.
Notably, multivariate logistic regression analysis identified the minimum value in platelet count as the only predictive factor of filter clotting during DrotAA infusion.
Furthermore, in a multivariate logistic regression analysis, they identified the minimum value in platelet count as the only predictive factor of filter clotting during DrotAA infusion.
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