Sentence examples for minimum plasma levodopa from inspiring English sources

Levodopa concentration was also determined in the sample taken at time 0 and it was considered as minimum plasma levodopa concentration (Cmin).

Compared with IR CD-LD, IPX066 also reduced the levodopa Cmax/ Cmin (minimum plasma drug concentration) ratio (12.0 ± 18.5 vs. 82.2 ± 67.5) and fluctuation index (1.5 ± 0.4 vs. 3.2 ± 1.3) at steady state.

Mean plasma levodopa concentrations were within 3% of their 1200 ng/mL target at 20 and 40 min into the infusion, and within 20% between ∼12 and 90 min.

Thus an effective procedure for sensor variable selection with minimum plasma knowledge is needed to develop in plasma etching.

Maximum plasma levodopa concentration (Cmax) and the time to reach maximum concentration (tmax) were read directly from the individual plasma concentration-time curves.

As the disease progresses, the synaptic dopamine concentrations and clinical effect become strictly dependent on plasma levodopa concentrations, and the factors affecting peripheral levodopa pharmacokinetics become critical to the therapeutic response [ 9, 28].

It was designed to rapidly achieve therapeutic plasma levodopa concentrations and maintain them for a prolonged duration to allow a dosing interval of approximately 6 h in both early and advanced disease [ 22].

which demonstrated that the average intra-subject coefficient of variation, calculated using standard statistical methods, for the plasma levodopa concentrations was 14% during continuous duodenal infusion of LCIG vs. 34% during oral therapy (P < 0.01) 9.

IDV PK parameter estimates included area under the plasma-concentration-time curve from time 0 to 8 hours after the dose, (AUC0 8 hrs), maximum plasma concentration (Cmax), minimum plasma concentration (Cmin), and time to maximum plasma concentration (Tmax).

This model predicted that a minimum plasma concentration of 20 nM is required to effectively inhibit BCR-ABL activity.

The minimum required plasma dilution of 1 20 was determined based on the potential for interference by known plasma components such as inter-α-inhibitor (34).