Sentence examples for minimum plasma concentration from inspiring English sources

For example, it is very difficult to determine if the observed efficacy is driven by maximum plasma concentration (C max) or minimum plasma concentration (C min) when such a steep drop of DCU plasma exposure is encountered [14].

This model predicted that a minimum plasma concentration of 20 nM is required to effectively inhibit BCR-ABL activity.

The initial sample size of the present study is calculated from the difference of minimum plasma concentration of nevirapine between the two groups of patients [ 12].

In addition, it is not possible to deduce a minimum plasma concentration or quercetin dose required for a specific biological activity.

The minimum plasma concentration (Cmin) of total and unbound darunavir was on average 43 86% and 10 14% higher, respectively, during pregnancy vs. postpartum.

This fits well with a recent hypothesis [ 37] that attributes CMS nephrotoxicity to the minimum plasma concentration of colistin, as already demonstrated for aminoglycosides [ 38].

The minimum plasma concentrations (Cmin) of olaparib were maintained during 28 days of treatment (400 mg bid: day 8, 3.6±2.2 μg ml−1; day 28, 3.9±2.6 μg ml−1) indicating that PLD did not interfere with steady-state olaparib plasma concentrations.

A linear mixed model analysis of log-transformed steady-state pre-dose minimum plasma concentrations (Cmin) normalized to the dose of 10 mg/day, including the cycle as fixed effect and the patient as random effect, overall mean, 90% CI, and inter- and intra-patient variability, were estimated.

Measures of total nicotine absorbed (AUC), maximum plasma nicotine concentration (Cmax) and minimum plasma nicotine concentration (Cmin), were higher for the 21-mg, 24-h patches than for the 15-mg, 16-h patch during both the first day of dosing and during the modeled steady-state period (48 72 h after initial application).

The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (Cmin) over 24 hours well above the 50% inhibitory concentrations (IC50) of patient-derived HIV-1 isolates [ 15].

Levodopa concentration was also determined in the sample taken at time 0 and it was considered as minimum plasma levodopa concentration (Cmin).