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The K-means can actually be proven to converge to a local minimum of expression (9) (Bottou and Bengio 1994).
A slightly different distribution emerged when genes were ordered by minimum of expression.
Many genes had minimal expression throughout the enteric stages, but there were also a large number of genes with minimum of expression between the tachyzoite and bradyzoite stages.
Reg3α was down-regulated with a minimum of expression at 7 h, followed by an increase which was maximal at 7d (Fig. 3A).
Quite a number of conserved motifs were found in co-regulated genes, whether when ordering genes by the maximum or minimum of expression.
MRP3 could be an important target for immunotherapy, if the expression of MRP3 RNA by gliomas and minimum of expression in normal brain is reflective of actual MRP3 protein expression.
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These filters operate by removing genes from the co-expression analysis that fail to show a minimum ratio of expression change (R) in a minimum number of microarray experiments (M), thereby eliminating the genes most likely to be unresponsive in the array set being analyzed.
A subset of more highly expressed rye reference sequences with a minimum level of expression of at least 10 transcripts in any rye tissue-specific library and not detected in all triticale libraries were selected for further analysis.
On a genome-wide scale, the number of genes favoring each of the parental alleles approaches a normal distribution curve (using 2.0× fold minimum level of expression; P < 0.05) (Fig. 1).
Potential co-expression relationships were checked for every possible regulator-gene pair given the minimum number of expression measurements in the chosen time window was four.
The number of clusters was manually reduced to eight, which represents the minimum number of expression profiles considering three time-points.
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components of expression
requirements of expression
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