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The computational efficiency of cloneHD is achieved with a fuzzy data segmentation scheme: HMMs are allowed to change their state only at loci where the data itself support a certain minimum jump probability.
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Transition matrices showing the jump probability between different zones are illustrated in Fig. 3.
Therefore, it is able to reflect the keyterm frequency by assigning the jump probability according to the keyterm frequency.
Then it runs Topical PageRank on each topic, where the jump probability is related with its occurrence probability under the current topic.
Wunderlich and Mirny (2008) estimated that the jump probability is Pjump=0.1675, which leads to six slides before a jump.
We found a jump probability of 1% or greater to be a good compromise.
filterHD not only is a powerful probabilistic smoothing algorithm but also produces a posterior jump probability track, highlighting regions of the data where real jumps in the emission rate could have occurred.
For felons, that mandatory minimum jumps up to five years.
We call the parameter λ the jumping probability.
Second, the robustness of λ (jumping probability) has already been discussed [15 17].
Let (lambda ) be the jumping probability the random walker jumps from the network of genes/proteins to the disease similarity network or vice versa.
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