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Thus, can only be rejected if also a minimum efficacy in is observed.
In particular, population structure favors adaptive immunity and reduces the minimum efficacy that is required for it to reach fixation.
Simulation results suggest the minimum efficacy of the drug with a particular amount in the cancer-cells invasion.
The minimum efficacy requirement to move to the randomised phase of the trial was an objective response rate of 20% or greater after four cycles of treatment.
Minimum efficacy component: A two-stage procedure will be conducted to determine if the individual novel experimental treatments achieve a minimal level of efficacy that would signify that the therapies are sufficiently promising to warrant further investigation.
The 60 s application time and the 2 × 3 ml volume for reference alcohol do not reflect clinical practice, but are well-accepted standards for determining the minimum efficacy of hand disinfectants in healthcare [ 3, 6- 8].
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In this paper, we extend EWOC to Phase I/II clinical trials by controlling for under-dosing with a Gumbel Copula model to provide patients with at least minimum drug efficacy.
Personalized medicine aims to determine the most adequate treatment and dose regimen to obtain the maximum efficacy and minimum side effect by taking into account patients' characteristics.
As gefitinib is not a traditional cytotoxic agent, dose selection for further study was based on identification of the optimum biological dose, combining maximum efficacy with minimum adverse events (AEs).
Three different breakup mechanisms are hypothesized that help explain experimental observations, including a minimum in breakup efficacy (ability to create smaller droplets) versus velocity data.
Furthermore, patients recruited from Japan had greater mean % predicted FEV1 values than the Not-Japan patients.> -wrap-foot> FEV 1 forced expiratory volume in one second, min minimum, max maximum Efficacy population consists of data from studies HZA106827, HZA106829, and HZA106837.
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