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†Mean minimum effective concentration was compared.
The minimum efficacious dose is 160 mg day−1 (level of evidence: B1).
If minimum efficacious dose of ruxolitinib cannot be maintained, then consider alternative therapy, including other JAK inhibitors.
If a minimum efficacious dose of ruxolitinib cannot be maintained, then consider an alternative treatment modality, including participation in clinical trials.
In terms of the calculation itself, the DR50 is estimated as the minimum efficacious dose according to the approved product information.
The accuracy of the estimate of minimum efficacious dose may differ among drugs and subjects with different pharmacokinetic and pharmacodynamic characteristics.
For this study, a minimum efficacious dose was defined as that dose effecting >25% reduction at study termination (that is, three hours post last dose).
Efficacious concentrations of this compound are also well tolerated by mice, making it an attractive prospect for clinical use [ 97].
This may further suggest the utility of BW-based dose when the efficacious concentrations completely saturate the targets.
Further clinical trials are needed to examine the safest and most efficacious concentrations of the various agents, particularly hypertonic saline.
Antibiotic drug release in a localized environment can target a bacterial infection at an efficacious local concentration, above the minimum inhibitory concentration (MIC), while reducing risk of systemic toxicity and antibiotic resistance development3,4,5.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com