Sentence examples similar to minimum effective final concentration from inspiring English sources

Because of these fluctuations in drug plasma levels, the drug concentration could fall below the minimum effective concentration or exceed the minimum toxic concentration.

It has been reported as a narrow therapeutic index drug that may cause severe nephritis and neurotoxicity at high concentration and fails to produce pharmacological effect below minimum effective concentration [ 13].

Analgesic effect is related to serum drug concentration; the minimum effective concentration (MEC) defines the level of serum drug level required to provide analgesia [ 19].

For CAS, the minimum effective concentration (MEC) was the first drug concentration to inhibit normal hyphal development.

The minimum effective plasma concentration (MEC) of combined CQ plus desethylchloroquine considered effective against CQ-susceptible parasites is ∼12 ng/mL [ 1, 19].

Background and Objectives: Whether patients titrate themselves to an individualized blood or plasma opioid concentration (the so-called minimum effective concentration or [MEC]) has been debated extensively.

A pharmacokinetic study has recently shown that in cotreated patients, nevirapine concentration was below the minimum effective concentration during initiation with dose escalation.

The disinfectant was monitored by the endoscopic nurse (Miss Ching-Yin Huang) every morning using test strips, and was discarded within 14 days if the concentration dropped below the minimum effective concentration (MEC).

This study demonstrated that OZ439 was safe and well tolerated at dose levels that provided prolonged plasma exposure with concentrations exceeding the estimated minimum effective concentration for ∼96 h.

The level above maximum safety concentration would lead to toxicity and level below the minimum effective concentration results in lack of efficacy.

Levels above the minimal tolerated concentration may result in serious toxicity, and levels below the minimum effective concentration will be subtherapeutic.