Given the effectiveness of the innate immune response, there is often a minimum effective dose of inoculated microorganism.
For example, some authors considered designs for simultaneously identifying the minimum effective dose, the lowest dose that achieves a target anti-tumor effect, and the MaxED [ 2, 10].
In the conclusions of a 321-page "medical officer review" dated Nov. 9, 1987, he described the proposed 10-milligram dose of Claritin as "minimally effective versus placebo" and added that 40 milligrams appeared to be "the minimum effective dose".
Government and European drug safety advisers stipulated that the "minimum effective dose" of HRT should be used for the "shortest duration" to treat menopausal symptoms such as hot flushes, night sweats and vaginal dryness.
In both studies, the minimum effective "dose" of carbohydrates was at least six or seven grams for every kilogram of a person's body weight, or about a quarter-ounce of carbohydrates for every 2.2 pounds of body weight.
One can only hope that the issues raised – namely what is actually the minimum effective dose, how best to administer possibly partially efficacious doses to reduce the burden of disease, and how to improve vaccine yield – will better prepare us in our ongoing battle with this very old enemy.
25 mg sumatriptan was the minimum effective dose [6].
The minimum effective dose of the modified extension domain was 1.0 mg/kg, which is 1/2000 that of ovalbumin.
The minimum effective dose of ET-3 in the secretion of ghrelin and GH was 0.4 μg/kg.
After one week, if the patient is asymptomatic, the dose should be decreased to the minimum effective dose at which the patient remains pain-free.
Compound 19e also exhibited satisfactory brain penetration, and suppressed PCP-induced hyperlocomotion with a minimum effective dose of 0.3 mg/kg by oral administration in mice.
