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A minimum inhibitory concentration (MIC) was defined as the minimum dose at which the formation of fluorescent puncta was inhibited in >95% of the cells.
In case of screening HbA1c ≤8.0%, the sulfonylurea dose was decreased by ≥25% (or stopped in case of minimum dose) at randomization in order to decrease the risk of hypoglycaemia.
The maximal effect occurred at 1 ng/ml Dex, which, perhaps tellingly, also happens to be the minimum dose at which Dex nearly completely suppresses activated T cells on its own.
The maximum allowable dose was defined as the minimum dose at which two out of three or more of the patients experienced adverse effects of grade ⩾2 in parenchymal organs (i.e., heart, liver, kidney, blood and lungs), according to the Japanese Society of Clinical Oncology Adverse Effects Form (Furue et al, 1986).
Even though NOAEL/LOAEL values can be queried from the database, the current analysis uses LELs, which do not reflect the NOAEL/LOAEL regulatory determinations derived from the studies and refer only to the minimum dose at which a specific effect or group of effects occurs.
According to the defined course of the catheters, the clinical target volume and the predefined minimum dose at the tumor margin (15 Gy, delivered as a single fraction), the planning software (Oncentra, Nucletron, Veenendaal, The Netherlands) calculated a dosimetry and the dwell of the Iridium-192 source inside the brachytherapy catheters, respectively.
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Based on our experiments, we have determined the optimized dose to be the minimum dose (300 mJ/cm2) at which enough photo-acid generators are turned into cations.
More recently, it is found that the apoptosis of testicular germ cell in mice is induced at the minimum dose of 20 μT at continuous exposure to a 60 Hz MF for 8 weeks and the minimum duration is 6 weeks at continuous exposure to 100 μT [ 21].
Patients were required to have received MTX therapy at a minimum dose of 15 mg/week for at least 3 months, with the dose having been stable for a minimum of 28 days prior to randomisation.
To induce apoptosis of testicular germ cell in mice, a minimum dose is 20 μT at continuous exposure to a 60 Hz MF for 8 weeks, and a minimum duration is 6 weeks at continuous exposure to 100 μT [ 21].
A total dose of 48 70 Gy at the isocenter was administered in 4 10 fractions at the minimum dose point in the planning target volume (PTV) using a 6-MV X-ray, comprising three different methods: 48 Gy/4 fractions; 60 Gy/10 fractions; and 70 Gy/10 fractions (Table 1).
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