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To evaluate the feasibility and the practical application for SERS detection in real-world samples based on GO sandwiched hybrid as SERS-active substrate, three different prohibited colorants with a series of concentrations were measured with a minimum detected concentration down to 10−9 M.
To explore this, we speculated that the variance of the unquantified PGEs would be high, if the variance of the minimum detected concentration of the 405 compounds were high among the 381 samples.
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The population median wet-weight serum PCB concentration and the minimum and maximum detected concentrations of each PCB congener are shown in Supplemental Material, Table 1 (doi:10.1289/ehp.0901444).
Indeed, parallel testing performed from serial dilutions of a filarial antigen (DATH) [ 26, 27] have shown that the ICT card test was weakly positive with antigen diluted 1/4, higher dilutions being clearly negative, and the minimum concentration detected by the test strip was two to four fold lower than the minimum detected using ICT card test [ 26].
Thus, the minimum concentration of antigen detected with the test strip was two to four times lower than the minimum detected with the card test.
Similarly as described for the IL-6 ELISA, a content of 0 pg/mL was assigned if the amount of VEGF detected was less than the minimum detectable concentration.
In the design of the photoacoustic detector, particular emphasis was placed in attaining a high sensitivity in detecting ethylene (ET) down to sub-parts per billion level (minimum detectable concentration 0.2 ppb).
The lowest concentration of analyte (anti-PA IgG) that can be detected with a specific degree of probability in a diluted serum sample is defined as the minimum detectable concentration (MDC).
Based on the minimum detectable concentration of GNRs of ~10 particles/ml under laser light fluence of 4 mJ/cm, about 100 particles per cell can be detected using the current system.
Minimum detectable concentration (MDC) for insulin was 50.9 pg/ml.
The minimum detectable concentration for cotinine was 3 ng/ml.
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