The corresponding minimum detectable ORs under a recessive model are 1.54 and 2.11.
Using the distribution of risk factors in our sample, a binary outcome (control vs uterine sarcoma), power of 80% and a two-sided α of 0.05, we calculated minimum detectable ORs for each risk factor, which ranged from 1.45 1.89 for factors associated with increased risk and 0.35 0.67 for protective factors.
The minimum detectable OR in quintile 5, assuming a linear trend in ORs, a power of 80% and a critical value of 0.05, was 0.56.
Since this latter design is not feasible, formulae at equation 25 allow determination of the minimum detectable difference (or maximum achievable power from equation 27).
16 Sample size was determined assuming a 35% prevalence of TC≥200 mg/dl in the NNTI-based group, a minimum detectable unadjusted OR of 2, a Type I error of 5% and a power of 80%.
Possible approaches include treating all undetectable measurements as zero, assuming all undetectable measurements are less than the minimum detectable data or assuming all undetectable measurements are less than some specified threshold.
aTwo-sided test, significance level = 0.05, power = 0.80 Since Aim 2 and 3 will be assessed via linear models with adjustment for multiple confounding, we calculated minimum detectable additional (or incremental) proportions of variance in the dependent variable explained by infant feeding practices (denoted ΔR) over and above that already explained by a given set of confounders (denoted R).
Designing a CRCT with a fixed number of clusters might mean that the study will not be feasible, leading to the notion of a minimum detectable difference (or a maximum achievable power), irrespective of how many individuals are included within each cluster.
No study reported sample size calculation, sufficient power to detect an important difference or minimum detectable difference on values of bone mass between grades of physical activity.
The semi-variograms showed purely random distribution of the scores from 6 10 to > 150 m of inter distances between observations, thus allowing to calculate the number of spade tests required to reach objectives of accuracy or minimum detectable difference.
Accuracy and precision of each device was evaluated as a function of the activity contained in the sample in order to estimate a threshold value, or minimum detectable activity (MDA), which, according to our operational definition, may be used to express the concept of Limit of Quantification (LoQ).
