Your English writing platform
Discover LudwigSuggestions(1)
Exact(1)
Briefly, coverage can be understood as the prior expected proportion of conserved bases in the regions being analyzed, and smoothness as prior expectation of the minimum conserved element length (=1/β).
Similar(59)
Conservation scores can be considered as probabilities that each SNP lies in a conserved element [48].
A conserved element in either −10 or −35 box of σB-promoter is sufficient to promote the synergism.
We identified two such motifs within a candidate NHEK regulatory region upstream of the IL1B TSS, with one motif overlapping a conserved element (Additional file 17, part C).
An additional distal conserved element sits around −850 to −1000 bp region (Figure 1A).
Abnormal action of conserved element can lead to genetic diseases [ 8].
We eliminated three very short conserved elements (< 8 bp, the minimum size required by MEME), and used the remaining 91 sequences (total length ~2.4 kbp) as input to the MEME algorithm.
Vertebrate conservation was obtained from the UCSC Genome browser [ 7], using the vertebrate conserved elements track (Vertebrate Multiz Alignment & Conservation (46 Species): Vertebrate Conserved Elements) with a minimum LOD score of 700.
Therefore, in terms of conserved TFBS's and conserved elements, each CpG island is characterized by 210 (115 × 2, for conserved TFBS's) plus two features (for conserved elements).
These evolutionarily conserved elements are most likely to be the structural bases of a common, ligand independent, signal transduction mechanism of class-A GPCRs.
The function of intergenic conserved elements is largely unknown [33].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com