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The obtained microspheres can efficiently encapsulate BMP-7, and release it in a controlled manner with minimum burst effect for over two months while maintaining protein bioactivity.
The obtained microparticles efficiently encapsulated BMP7 and released it in a controlled manner with minimum burst effect for over two months while maintaining protein bioactivity.
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The scaffolds showed the sustained release of both proteins over four weeks, with minimal burst effect.
However, there is a serious burst effect at 22°C.
For pNIPAM/IP NFs, there is a significant burst effect at 22°C; whereas both diffusion rate and burst effect are dramatically depressed at a higher temperature.
No burst effect was observed for SA release from these pH-sensitive carriers.
For pNIPAM/IP/PCL composite NFs, burst effect was significantly reduced for both 22°C and 34°C.
The solar radio burst effect on the horizontal position error estimation is shown in Fig. 2c.
A burst effect is seen when the pH is at this later value.
It showed a prolonged, bi-phasic, release of bioactive BDNF, without burst effect.
These high oxybutynin solubilities were considered the major contributors to the burst effect.
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