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In order to define the minimum autonomous folding unit in p16, we have further dissected p16C into two complementary peptides, each containing a single ankyrin repeat.
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This paper considers a robot in the form of a self-folding sheet that is capable of origami-style autonomous folding.
Such autonomous folding units (AFUs) are of wide interest and have applications in protein engineering and as simple model systems for studying the determinants of stability and specificity.
BRCT possesses an autonomous folding unit defined by conserved clusters of hydrophobic amino acids, and BRCT is likely to represent a protein interaction surface (Saka et al, 1997).
First, a domain is less likely to form combinations if it does not have a robust, autonomous fold [ 28].
This chapter presents the identification, characterization, and possible uses of autonomous folding units (AFUs), with special emphasis on studies aimed at understanding protein architecture and folding.
Local minimum free folding energy profiles.
It is also frequently used in conjunction with minimum fold-change requirements (for example, 2-fold, 10-fold) so as to ensure biological relevance.
L3utr length of 3′ UTR, dG minimum folding energy.
Non-cell autonomous tissue folding that distorted the shape of the disc was apparent and, in some clones, cells adopted a more rounded morphology.
Such genomic regions were further filtered to include sequences with minimum 1.3 fold enrichment, and minimum −1.3 fold depletion.
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