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In general, erlotinib is associated with higher toxicity and lower tolerability than gefitinib because the dose of erlotinib used is nearly equal to the maximum tolerated dose, whereas the dose of gefitinib used is close to the minimum active dose [ 11, 12].
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Also, many of these agents may prove to be more effective in combination therapy either with synergistic targeted agents or with chemotherapy and the minimum biologically active dose needs also to be determined.
minimum active power limits of generators.
The minimum active concentration of CAG18439-conditioned medium was examined by diluting this medium.
The lowest active dose is 2.5 mg kg−1.
Very little, Allison says, is known about these, each of which has different active doses, different toxic doses, and different effects.
Unlike other pediatric dosing systems, our model provides active dosing assistance and dosing process management, not just static dosing advice.
Data for placebo and three active doses were simulated.
Published estimates were used to assign a minimum dose to the active bone marrow for various radiographic procedures.
NP603 was synthesized and found to be more active against endothelial proliferation of HUVEC after the rhFGF-2 stimulation than SU6668 with minimum effective dose of 0.4 μM but with similar potency as SU16g.
NP506, the 3-{2,4-dimethyl-5-[2-oxo-5(N′-phenylhydrazinocarbonyl -1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid, was desigN′-phenylhydrazinocarbonyl -1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrol-3-yl}-propionicst eN′-phenylhydrazinocarbonyl -1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrol-3-yl}-propionic effective dose of 10 μM.
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