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Treatment schemas emphasize the importance of minimizing toxicity and treatment duration, while attempting to improve therapeutic efficacy.
Modern chemotherapeutic approaches aim to improve survival duration and palliate symptoms while minimizing toxicity and maintaining quality of life [ 3].
Establishing ideal organ-specific delivery systems, while minimizing toxicity and off-target effects will be essential to moving the field forward [ 97].
The development of clinical oncology PKPD models may help to design subsequent trials towards minimizing toxicity and optimizing efficacy through establishment of an optimal dose, optimal regimen, for the optimal patient.
Further clinical data with long follow-up period are needed to ascertain the dose fractionations schedule that optimizes tumor control while minimizing toxicity and to better understand the optimal normal tissue dose volume constraints.
Good antimicrobial stewardship involves selecting an appropriate drug and optimizing its dose and duration to cure an infection while minimizing toxicity and conditions for selection of resistant bacterial strains.
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By ensuring the adequate representation of women in clinical trials, we hope to achieve the goal of optimizing care and minimizing toxicities and comorbidities for women living with HIV.
Our finding that multiple combinatorial interventions are effective enables the selection of those that are most effective drug targets and minimize toxicity and side effects.
Therefore, it is important to confirm tumour selectivity of a novel candidate mAb to minimize toxicity and maximize efficacy, preferably in early stages of drug development.
Identification of optimal timing and sequencing of adjunctive therapy, proper cytotoxic drug application, methods to further minimize toxicity, and heat-sensitive tumor types will lead to expanded clinical use of whole-body hyperthermia.
They can minimize toxicity and chronic inflammation.
More suggestions(15)
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