Sentence examples for minimizing toxicities of from inspiring English sources

To exploit anti-MM activities while minimizing toxicities of HDACi, class or isoform selective HDACi have recently been developed.

Apart from the challenges in optimizing pharmacokinetic properties and minimizing toxicities of lead compounds, the lack of publicly available/accessible biomedical assay data may represent another barrier for the success of drug discovery.

Moreover, establishing any potent biomarkers for chemotherapy resistance will allow for the adoption of a better chemotherapeutic regimen, which will maximize efficacies and minimize toxicities of chemotherapy.

To minimize toxicity of high-dose methotrexate (MTX) therapy, urinary alkalinization with frequent monitoring of urine pH is required.

Improving delivery techniques that minimize toxicity of drug has a significant effect on its efficacy.

This NSC-mediated therapeutic approach would overcome current limitations of standard therapies, while minimizing toxicity to normal tissues [19], [20].

Sequential single-agent chemotherapy is the treatment of choice for most patients with metastatic breast cancer due to a reasonable chance of response, successful symptom palliation, and improved quality of life while minimizing toxicities.

Kinetic Targeting is a much smarter variant of dose modification, and due to this trial's data, we propose a smarter way of minimizing toxicity and a lesser impairment of clinical efficacy by CARL than by a simple dose reduction.

Accordingly, investigation of the best optimal duration of HT with maximization of outcome while minimizing toxicity is a logical step in the management of localized high-risk PCa, because the prolonged use of HT may result in an increase in adverse events.

Treatment schemas emphasize the importance of minimizing toxicity and treatment duration, while attempting to improve therapeutic efficacy.

Modern chemotherapeutic approaches aim to improve survival duration and palliate symptoms while minimizing toxicity and maintaining quality of life [ 3].