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Inhibition of IMPDH significantly increased the sensitivity of the resistant cell lines to MTX, indicating that targeting IMPDH might constitute a promising means of minimizing the development of resistance [20], [21].
First, there is the hope of minimizing the development of resistance against major P. aeruginosa active substances.
This knowledge will help in managing fungicide programs and maintaining effective control of powdery mildew while minimizing the development of populations increasingly resistant to DMI treatments.
This use may not always adhere to manufacturer-specific dosage and prescribing practices aimed at minimizing the development of carbapenem resistance in an effective manner.
A promising role of vitamin D supplementation in children with asthma is the potential of minimizing the development of a very early feature of airway remodelling, increased thickness of the reticular basement membrane (41, 42), which would incorporate a novel therapeutic target in asthma.
Improvements in service delivery are also needed to ensure that ART is started early and to promote adherence to lifelong treatment, which is crucial to maximizing the prevention and treatment benefits of antiretroviral (ARVs) drugs and minimizing the development of drug resistance.
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We focus on strategies of targeted drug combinations to minimize the development of drug resistance within the context how resistance develops.
Understanding the locations at risk for biofilm formation can aid orthodontists and patients when introducing preventive strategies to minimize the development of WSLs.
Successful use of anticancer designer drugs is likely to depend on simultaneous combinations of these drugs to minimize the development of resistant cancer cells.
Background: Early and intensive glycemic control is necessary to prevent or minimize the development of microvascular and macrovascular complications in individuals with type 2 diabetes mellitus.
In an insightful review and commentary on ANA testing [11] M. Fritzler points out that the early detection of autoimmune disease is critical to ensure that treatment is promptly administered to minimize the development of disabling conditions.
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