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We have designed a new bioreactor system to increase the efficiency of biological treatment systems by (1) allowing greater organic loads, (2) minimizing production of sludge waste by-products, and (3) increasing process stability and resistance to shock loading.
This study also contradicts the hypothesis that both chemotypes have all the machinery needed to produce both atranones and satratoxins, but there is a strain-specific metabolic shunt at work minimizing production of one type of toxin or the other.
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To minimize production of xylitol, a major by-product in xylose metabolism and concomitantly improve ethanol production, Saccharomyces cerevisiae D452-2 was engineered to overexpress NADH-preferable xylose reductase mutant (XRMUT) and NAD+-dependent xylitol dehydrogenase (XDH) from Pichia stipitis and endogenous xylulokinase (XK).
32 Reconstitution of the lyophilized degarelix powder involves addition of sterile water to the product vial followed by swirling to minimize production of foam.
Using p-nitrophenylalanine as the nonnatural amino acid and streptavidin as the target protein, tRNA sequences and the types of four-base codons were optimized to maximize the yield of the nonnatural mutant and to minimize production of full-length proteins that do not contain the nonnatural amino acid.
We should take actions to minimize production of greenhouse gases, environmental pollutants, hazardous waste and other materials that can impact life on Earth.
Inhibiting activation of the classical pathway at the level of C1s should result in decreased complement deposition on the cell surface, as well as minimize production of anaphylatoxins.
It is also possible that a slower cell cycle allows for more efficient DNA repair, a lower DNA replication error rate, or lower metabolic demands on the cell that minimize production of DNA-damaging free radical species.
It is likely that the loss of mitochondria in hypoxic skeletal muscle is an adaptive response, which aims to minimize production of harmful reactive O2 species (ROS) such as superoxide.
Increased depth of tissue penetration by infrared light along with confinement of excitation to the vicinity of the laser focus are especially attractive features of this approach, as they minimize production of toxic byproducts of the triplet quenching reaction (e.g., singlet oxygen) and allow high-resolution sampling of oxygenation at depth in tissue.
Hydroxymethyltransferases play a critical role in controlling the cell damage caused by abiotic stresses such as high light and salt, supporting the notion that photorespiration forms part of the dissipatory mechanisms of plants to minimize production of reactive oxygen species (ROS) in the chloroplast and to mitigate oxidative damage [ 39].
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