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During the dose optimization process the dose constraints were adjusted to obtain adequate and homogeneous target volume coverage while minimizing dose in heart, spinal cord, and both lungs.
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Protons have also been used in the treatment of prostate cancer to achieve dose escalation while minimizing doses to normal tissues [ 23].
NPC bell shape like lesion treatment planning method is based on dose bricks concept which can provide maximum target dose and minimize dose of critical organs, especially in parotid glands.
However, as dexamethasone may be associated with a range of side effects, there is interest in minimizing its dose and frequency, particularly in those patients who experience dexamethasone-related side effects or in those with preexisting conditions that may be exacerbated by corticosteroid use.
However, the low mAs imaging parameters were used to minimize this increased dose in this study.
Our clinical study also confirmed the dosimetric experience of other investigators about the potential of Tomotherapy for improving target coverage while minimizing radiation dose to the normal tissues in head and neck cancer patients.
Advances in radiotherapy techniques allow targeted treatment of the disease, whilst minimizing the dose to organs at risk.
We used additional IVIG (0.4 g/kg/day for 5 days), albeit early in the course of the disease, and also expected to minimize the dose of corticosteroids in the first trimester.
In addition, our work indicates that the use of folate in combination with ABT-737/etoposide can markedly enhanced the response of LGG cells to ABT-737/etoposide and may minimize the dose of ABT-737 in order to reduce the ABT-737-induced co-lateral damage, even if this drug is generally well tolerated (Oltersdorf et al. 2005; Konopleva et al. 2006).
The PTV was retracted 5 mm from the patient surface (PTVtrim) to minimize high-dose levels in the build-up regions for IMRT plans.
These effects are dose related and can therefore be minimized with dose reduction [5].
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