Thus, optimization of gene expression is required to prevent accumulation of the toxic metabolites and to minimize burden.
The emphasis in this review is on questionnaire-based instruments that minimize burden on the investigator and the participant.
Creation of bispecific antibody from four individual amino acid sequences (different light and heavy chains) is a process which must be optimized to minimize burden on downstream processing.
Measures collected are anonymized and shared among scientists to maximize collaborative value and to minimize burden on the families.
We sought to develop scales that provide sufficient measurement precision and breadth, yet minimize burden and cost.
A more detailed set of questions would have been preferable; however the questionnaires were designed to be concise to minimize burden on the respondents and remain within budget.
A maximum of 10 participants were recruited on any given day to minimize burden in the department and to hopefully capture a wider spectrum of medical conditions.
The classic challenge of instrument development is to arrive at the correct number of items to minimize burden and avoid redundancy, while including a sufficient number to be comprehensive.
It also supports the results of previous research showing that virtual panels may potentially expedite the elicitation process, minimize burden on participants, allow the conduct of larger and more diverse panels, and include geographically distributed participants [ 8, 9].
To minimize burden on both healthcare professionals and patients, existing data sources (e.g., electronic medical records, prescription dispensing records, healthcare claims databases) should be leveraged to the full extent possible [ 66, 67, 68].
