Exact(1)
To allow dose escalation of temozolomide while minimizing bone marrow toxicity, a phase I trial (NCT01269424) has been initiated for adult glioblastoma multiforme patients.
Similar(47)
In fact, the lower doses and shorter infusion times used with weekly dosing should minimize bone marrow suppression and other toxicities associated with standard 3-weekly schedules, while maintaining the dose intensity necessary for anti-tumour activity.
Because the radiation is targeted to the bone tumors, damage to other tissue, including bone marrow, is minimized, the researchers said.
To minimize post-mortem changes in bone marrow MR-signal characteristics and signal-to-noise after freezing and thawing [ 26], we did not freeze the cadaver and evaluated the intact knees as quickly as possible (within 36 hrs of death).
We hypothesized that this conservative threshold would cause MR-based apparent BV/TV to systematically underestimate microCT-based BV/TV but also minimize the influence of abnormal bone marrow signal on MR imaging.
While MSCs have been successfully cultured from a number of mammalian species, we sought to develop a simple, straightforward technique for the isolation and culture of mMSCs that requires minimal MSC manipulation (sorting, enrichment, depletion, etc). and minimizes the time from the bone marrow niche to plating, all while enhancing cell proliferation and differentiation potential.
Donating bone marrow?
Of the bone marrow.
Bone Marrow Transplant.
Bone marrow biopsy.
"You do for bone marrow".
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