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A key advantage of combination therapy using synergistic, or even additive, cocktails is the reduction in drug concentration, which minimizes the toxicity and side effects of many antimicrobials to the host.
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These include (1) minimal tissue dissociation in order to minimize the toxicity of collagenase over-digestion, (2) the preferred use of NOD scid gamma (NSG; NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ JAX) mice, (3) co-implantation of cells with Matrigel, and (4) patience, since tumour formation may take up to 6 months.
This method leads to minimize the toxicity of the chemical materials used to nanoparticle synthesis.
Therefore, the removal or minimizing the toxicity of the metal ions from wastewaters has been a matter of great concern.
Nevertheless, to minimize the toxicity and side effects, it would be ideal to preserve the chemokine receptor activity.
Therefore, dilution of the sugar mill effluent is necessary to minimize the toxicity of sugar mill effluent and it has the potentiality as organic fertilizer.
These PU materials are expected to minimize the toxicity from synthetic petrochemical-based polyester and enhanced the biocompatibility of the PU products.
Two strategies have been utilized to minimize the toxicity of dendrimers: first, selecting neutral or anionic biocompatible dendrimers, and second, masking of peripheral charge by chemical modification.
To improve the activation of irinotecan and address issues of overaccumulation in the blood, a liposomal encapsulation of irinotecan (MM-398) was designed to minimize the toxicity of the drug as well as achieve a higher efficacy [66].
The reduced activities of NR and NiR in stressed plants may have minimized the toxicity of excess NH4+ (Wang et al. [2007]) by inhibiting the conversion of NO3−-N to NH4+-N and reducing NO3−-N uptake.
The kinetic model was useful to give early insights into the most appropriate bioconversion conditions, which can improve the rate and yield of ABT formation, as well as minimizing the toxicity and inhibition effects of the substrates and products.
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