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This constitutes a minimized design yielding a small two-domain structure with a molecular weight of 26 kDa.
This is the first report on the in vitro and in vivo activity of a Nanobody using this minimized design.
This format constitutes a minimized design, yielding a small structure which conveys high potency, as well as promising PK properties and in vivo efficacy.
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In an energy-minimized design, the set of nodes corresponds to IP routers and optical switch nodes, and the link set symbolizes the physical fibers in the network.
The minimized test design yielded similar bioconcentration results as those of the standard test and has potential for its use in screening approaches for pharmaceuticals and other classes of chemicals.
In a minimized bioconcentration test design, channel catfish (Ictalurus punctatus) were exposed to 250 μg L−1 for a week and allowed to depurate for 7 d.
One case study will show how the original design minimized equipment damage from an operational error, and how additional safeguards will prevent recurrence.
The contacts between antigen and neutralizing antibody define a structural epitope, and methods have been developed to transplant epitopes to scaffold proteins for structural stabilization, and to design minimized antigens that retain one or more key epitopes while eliminating other potentially distracting or unnecessary features.
First, the randomized controlled study design minimized bias and confounders.
Although the prospective randomized design minimized baseline imbalances, some differences were evident owing to the small sample size.
This design minimized bias due to awareness of treatment assignment, which could occur with either a parallel group or a two-period crossover design.
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