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The method adjusts both concentration scale and levels of constant background to minimize variance in the ensemble.
To maintain the purity of the quasi-experimental framework, it is crucial to minimize variance in the interviewer's performance and, especially, to quash any potential tendency to inference and interpretation or any tendency for the patient to veer from the initial question.
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As the Bcd variance can be exaggerated in the data normalized by the basic method, we considered the same ensemble of Bcd profiles but normalized by the alternative artificial normalization method, which minimizes variance in the ensemble (see Methods).
Within this narrow age band, normally developing adolescent girls can be at any puberty stage from Tanner stage 1 to 5 (Marshall & Tanner, 1969), thereby providing maximal pubertal variability while minimizing variance in age.
However, because there is no independent reason to believe that background should be adjusted to minimize variance, the in situ data processed in this manner should be viewed as a lower limit on embryo to embryo variation of the Bcd profile.
Only HPAEC and HPVEC pairs, i.e. isolated from the same placentas, were used in order to minimize variance.
The probe sequence from each candidate target was blasted against the NCBI Picea EST libraries and nucleotide collection databases, from which nucleotide alignments were constructed for primer selection (Additional files 4 and 5), which was based primarily on positioning the amplicon close to the stop codon in order to minimize variance due to partial reverse transcription.
In both cases, statistical concerns to minimize variance are balanced by logistical concerns to minimize number of assessments.
Narrow velocity ranges are recommended to minimize variance.
The goal of the MDS-MAP is to produce a topology map that minimizes variance of links of all pairs of nodes in the network; whereas, the proposed algorithm minimizes variance of links of all pairs of local neighbors.
minimizing variance for a specified cost. .
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