Thus, they can stimulate, respond to, and interact with target cells and tissues in controlled ways to induce desired physiological responses while minimizing undesirable effects.
To minimize undesirable side effects on the cell cycle, which could disturb the direct effects of heat shock on general transcription and mRNA stability, we employed mild stress conditions that minimally affected exponential growth (cells continue growing, see Fig. 1), but still induced the expression of the genes taking part in the heat shock response.
Such carriers can maximize therapeutic efficacy and minimize undesirable side effects by decreasing their dosage.
Our goal was to investigate if a branched DNA/RNA hybridization technique can be developed into a simple clinical assay for predicting GC sensitivity in newly diagnosed and relapsed ALL patients, such that the use and dosage of GCs could be tailored specifically to the patient and minimize undesirable adverse effects.
Performances of intelligent drug delivery systems are continuously improved with the purpose to maximize therapeutic activity and to minimize undesirable side-effects.
To this end, Finite Element models were developed and their results were used to propose a geometry which minimizes undesirable effects such as stress concentrations, develops a uniform state of biaxial stresses in the central zone of the coupon and assures that the failure takes place at this zone.
Based on the observation that such "lousy" miRNAs have few targets, it was proposed that designing siRNAs with weak SPS and high TA would minimize undesirable off-target effects.
The optimization problem emphasizes actuator accuracy and it is formulated to yield optimal compliant mechanism configurations that maximize the desired output displacement when a force is applied, while minimizing undesirable thermal effects.
