By minimizing substitutions we are able to establish a relation between indels that could have occurred in the same position of the compared genomes, identifying genomic regions that could be subject to these continuous mutations.
The aim is to avoid or minimize hazards by substitution of benign materials, moderation of conditions and simplification of operations in process plant.
To address this risk, the FDA has recently published draft guidance that calls for the addition of a unique suffix to the INN for all biologics, including biosimilars, to differentiate products and minimize inadvertent substitution [ 36].
The LOS scores, therefore, indicated the pattern of substitutions that are predominantly due to their thermal adaptation and therefore minimize the effect of substitutions due to any speciation events in the evolution process.
This substitution minimizes premature hydrolysis of GyrA-fusion proteins during expression, thereby facilitating analysis of the target peptide sequences after chemically induced splicing of the intein from the purified proteins in vitro.
To minimize the risk of such substitution, Mr. Smith said in his letter, states should charge co-payments or premiums that approximate the cost of private coverage and should impose "waiting periods" to make sure middle-income children do not go directly from a private health plan to a public program.
Branch lengths and topologies are optimized in order to minimize the amount of amino acid substitution that is inferred.
We always balanced the number of species in the sister clades, to minimize the effects of node density on substitution rate estimation [ 16].
A subset of gap opening and gap extension penalties was chosen to minimize the frequency of both single-nucleotide substitution and insertion/deletion events in order to provide the most biologically meaningful optimal global alignment (See Results and Discussion).
However, more recently, it has been demonstrated that the genetic code is quite nonrandom with respect to its ability to minimize the effects of single-base substitutions on proteins, especially at the first and third positions of the codon (Freeland and Hurst 1998).
