As established by the ROESY data, the energy minimized 3D structure of 1 revealed stereoconfiguration of 1.
Applying the feature mapping algorithm of CATALYST, several models were generated by placing pharmacophoric features on the chemical moieties of the energetically minimized 3D structure of anacetrapib.
Energy minimized 3D model structures of furin-Eda-peptide before and after Bergman cyclo-aromatization reaction were computed using hyperchem program and the structures were depicted in Fig. 9.
We also analyzed and edited mRNA structure to minimize co-variation of structure, internally or near the translational initiation site, with codon usage constraints.
The main goal of the structural optimization is to minimize the weight of structures while satisfying all design requirements imposed by design codes.
Vibration absorbers have widely been used to minimize the vibration of structures, either globally for rigid structures or locally for flexible structures.
An important and challenging problem is the determination of appropriate control structures that minimize the loss of process performance under the effect of uncertainties.
Molecular dynamics simulations were then used to energy minimize and equilibrate the structures of full-length PARP-1 and the PARP-1 8-mer comPARP-1 8-merRAL using NAMD version 2.9.
The approach is used to design the lateral load systems of structures that minimize the variance of the system response to stationary stochastic ground motion excitation.
Effective incentive systems require regulation and governance structures that minimize problems of patronage and corruption [ 43].
