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To minimize parameter explosion across our many stimulus conditions, we tested only a single dependent measure of the BOLD response.
Note that a small λ is already sufficient to minimize parameter changes, while the experimental data is still described very well.
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Though we attempted to use patient samples from matching decades of life, given the resources available, we erred to minimize parameters that would lead to degradation of RNA such as post-mortem interval and brain pH.
We therefore agree that, despite our wish to minimize parameters and avoid arbitrary cutoffs, requiring at least one (uniquely aligned, high quality) RNA read to support editing is reasonable.
The practical identifiability of each law is examined by generating synthetic 3D tags from in silico simulations, allowing mapping of the objective function landscape over parameter space and comparison of minimizing parameter values with original ground truth values.
Specifically, HOD selects those samples which minimize the parameter covariance matrix of the Hessian regularized regression model.
Therefore, it is natural to adopt machine learning approach into the knowledge-oriented controllers to enhance their performance and minimize tedious parameter tunings.
Algorithms such as SLIDE, NSMAP or others that explicitly enumerate the candidates and minimize the parameter in the candidate space also return one of several solutions.
In this case, the inoculum size of S. cerevisiae KE6-12 was reduced to 1 g/L in order to minimize this parameter and enable detection of differences after laccase treatment.
MAVES tool allows evaluating control algorithms in order to minimize some parameters.
From the evolution of strain and roughness with layer thickness as observed with these low-porosity monolayers, a direct guideline would be to grow layers that are as thin as possible, in order to minimize both parameters.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com